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Antiviral nasal spray can fight coronavirus, the study finds



A nasal spray that can protect against coronavirus has been formulated by researchers at the University of California, San Francisco, according to a report. Researchers are now working to test and produce it clinically.

The aerosol spray, called AeroNabs, is an antiviral that aims to prevent COVID-19, though it is not a cure, the researchers said in a statement. They added that it could be a good weapon against the new coronavirus until a vaccine is found, or a possible alternative for those who do not respond to a vaccine.

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“Far more effective than forms of personal protective equipment, we think of AeroNabs as a molecular form of PPE that can serve as an important stop until vaccines provide a more permanent solution to COVID-19,” said Peter Walter. , Ph.D. , professor of biochemistry and biophysics at UCSF and a Researcher at the Howard Hughes Medical Institute, in a press release.

“For those who cannot use or respond to SARS-CoV-2 vaccines, AeroNabs may be a more permanent line of defense against COVID-19,” added Walter, who is also the co-inventor of AeroNabs.

The scientists said in the release that they were inspired by nanobodes, which are like antibodies found in light bulbs and camels.

“Although they function much like the antibodies found in the human immune system, nanobodes offer a number of unique advantages for effective therapy against SARS-CoV-2,” said co-inventor Aashish Manglik, MD, Ph.D., an assistant professor of chemistry. pharmaceuticals, in a statement.

Koronavirus (COVID-19. (Rendering 3D)

Koronavirus (COVID-19. (Rendering 3D)
(edit: BlackJack3D / iStock)

The researchers explained that SARS-CoV-2 relies on peak proteins to infect human cells.

“They are the essential key that allows the virus to enter our cells,” they said.

The researchers explained that when the coronavirus particle is activated, the thymus receptors become premature to attach to ACE2 (the enzyme angiotensin 2 converter) found in human cells that leave the nasal passages, lungs and airways. Researchers in the field of coronavirus recently told Fox News that this is the entry point of the virus.

The authors explained in the report that they created “single-domain antibodies (nanobodies) that strongly disrupt the interaction between SARS-CoV-2 Spike and ACE2.” They were able to create synthetic nanobodes on a yeast surface and found that the nanobodes were riveted and blocked the ACE2 interaction, thus blocking the virus from invading the host.

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Investigators clarified in the news release that the most powerful nanoparticles act not only as a sheath surrounding the point receptors, but also as a “molecular mousetrap”, narrowing at the top in its closed, inactive state, which adds a layer additional protection against peak interactions – ACE2 leading to infection. “

The nanobodes remained a potent antiviral SARS-CoV-2 when tested in an aerosolized form, according to the announcement. These means it may be practical to administer by means of a shelf inhaler or nasal spray. This aerosol form could provide a “prophylactic therapeutic agent and / or early infection control to curb the worst pandemic in a century,” the researchers said.


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