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Home / Health / NorCal scientists develop COVID-19 antiviral nasal spray

NorCal scientists develop COVID-19 antiviral nasal spray



Scientists and UC San Francisco announced an absorbent defense against COVID-19 with the goal of producing an affordable, free antiviral drug in the coming months. The UCSF is working to initiate human trials over what they have dubbed “AeroNabs”. “This is a molecule that would bind to the coronavirus protein very strongly. And when it binds to the virus, it fully spreads its ability to infect human cells,” explained UCSF Assistant Professor and co-inventor Aashish Manglik. The COVID-19 virus has spike proteins capable of binding to a cellular receptor, becoming a host to produce more young coronavirus and spread the infection. “I like to think of it as a molecular tape,”

; Manglik said. “It tightens the virus, prevents it from ever releasing – and that’s basically what it is.” Manglik was able to turn AeroNab into an aerosol, which in turn could be used as a nasal spray or inhaler. “Really, the hope for what we have developed is basically to serve as a bridge until we have a vaccine that can be used a lot and can be used by the majority of the population,” Manglik said. “People like nursing home residents or health care workers, or people in plants for packing meat – things like that. High-risk people who can administer this molecule maybe once a day as a nasal or nasal injection. “Even with a vaccine available, it is one thing to have a vaccine that works, it is another thing to make it available on a large scale. And also, stable immunity for a large part of the population with a vaccine,” he said. Manglik. “And there may be some segments of the population that either cannot tolerate a vaccine or the effect of a vaccine diminishes faster.”

Scientists and UC San Francisco announced an absorbent defense against COVID-19 with the goal of producing an affordable, free antiviral drug in the coming months.

The UCSF is working to initiate human trials over what they have dubbed “AeroNabs”.

“This is a molecule that would bind to the coronavirus protein very strongly. And when it binds to the virus, it fully spreads its ability to infect human cells,” explained UCSF Assistant Professor and co-inventor Aashish Manglik.

The COVID-19 virus has spike proteins capable of binding to a cellular receptor, becoming a host to produce more young coronavirus and spread the infection.

“I like to think of it as a molecular tape,” Manglik said. “It tightens the virus, prevents it from ever releasing – and that’s basically what it is.”

Manglik was able to turn AeroNab into an aerosol, which in turn could be used as a nasal spray or inhaler.

“Really, the hope for what we have developed is basically to serve as a bridge until we have a vaccine that can be used a lot and can be used by the majority of the population,” Manglik said. “People like nursing home residents or health care workers, or people in plants that contain meat – things like that. High-risk people who can administer this molecule maybe once a day as an inhaler or nasal spray. “

UCSF said the research team is in active discussions with trading partners for clinical production and testing.

“Even with a vaccine available, it is one thing to have a vaccine that works, it is another thing to make it available on a scale. And, also, stable immunity for a large portion of the population with a vaccine, “Manglik said.” And there may be some segments of the population that either cannot tolerate a vaccine or the effect of a vaccine diminishes more quickly. “


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